Native - Human Neutrophils
Lactoferrin is an 80kDa iron binding glycoprotein produced by many exocrine glands. It is a major component of secondary granules in neutrophils. Lactoferrin displays diverse biological activities with key roles in microbicidal effects and activation of innate immune responses. The presence of lactoferrin in bodily fluids including the intestinal lumen is known to be proportional to the influx of neutrophils in that region and is therefore used as a reliable biomarker in inflammation related diseases and infections.
Recent studies have shown lactoferrrin to be a valuable marker when used in faecal assays. C.difficile infections, urinary tract infections, pouchitis and infectious diarrhoea are commonly tested for using assays targeting lactoferrin. It has also been reported to be found at higher levels in patients with Crohn’s disease in comparison to inflammatory bowel syndrome.
Lactoferrin autoantibodies have been detected in SLE and vasculitic diseases but specific pathogenic roles have yet to be determined and if any significance can be obtained from these results.
Inflammatory Bowel disease
Autoantibodies to lactoferrin have also been reported in:
Systemic Lupus Erythematosus
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