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ATN01

ATN01

NGAL

Native - Human Neutrophils
US $408.00
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Neutrophil gelatinase-associated lipocalin
Uniprot ID:  P80188
mRNA RefSeq:  NM_005564
Protein RefSeq:  NP_005555
NGAL, a 23kDa glycosylated dimer, is a member of the lipocalin family of exracellular proteins that play a role in the transport of small hydrophobic molecules. NGAL binds bacterially produced formyl peptides and can form complexes with the MMP-9 proenzyme form. It is found to be secreted into urine by the ascending limb of the loop of Henle, which more than likely plays a role in host defence and recycling of iron complexes by endocytosis.
 
NGAL is thought to also be a pivotal early biomarker for the diagnosis of acute kidney injury (AKI). AKI is a common complication and prognostic factor in the longterm outcome of patients undergoing liver transplantation. Creatinine has been a mainstay in the diagnosis of renal injury but it cannot distinguish between AKI, prerenal azotemia and chronic renal disease. The accumulation of creatinine can also lag behind the injury with delays diagnosis.

NGAL is found to increase with renal injury earlier than creatinine, with patient urine levels increasing significantly.

 
PDF-logo-dl NGALdatasheet
Acute renal injury
Various types of cancer
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  • Mishra, J. et al. (2005) Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker for acute renal injury after cardiac surgery. Lancet 365(9466):1231-8
  • Nickolas, TL et al. (2008) Sensitivity and specificity of a single emergency department measurement of urinary neutrophil-gelatinase-associated lipocalin for diagnosing acute kidney injury. Ann. Intern. Med. 148:810-9
  • Jeong, TD et al. (2012) Neutrophil gelatinase-associated lipocalin as an early biomarker of acute kidney injury in liver transplantation. Clin. Transplant. 26:775-81
  • Kjeldsen, L. et al. (1993) Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J. Biol. Chem. 268: 10425-32
  • Bundgaard, JR. et al. (1994) Molecular cloning and expression of a cDNA encoding NGAL: a lipocalin expressed in human neutrophils. Biochem. Biophys. Res. Comm. 202: 1468-1475
  • Coles, M. et al. (1999) The solution structure and dynamics of human neutrophil gelatinase-associated lipocalin. J. Mol. Biol. 289:139-157
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AROTEC Diagnostics
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