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ATE02

ATE02

Eosinophil Peroxidase (EPX)

Native - Human Eosinophils
US $443.00
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Eosinophil peroxidase
EPO
EPX
Uniprot ID:  P11678
mRNA RefSeq:  NM_000502
Protein RefSeq:  NP_000493
EPX, a heme-containing haloperoxidase, consists of a heavy chain of 50-57kDa and light chain 11-15kDa with a high content of both arginine and aspartic residues. Structurally related to myeloperoxidase, it is the most abundant granule protein in eosinophils. Granulocytes are known as early responders to microbial invasion leading to an inflammatory response. They have been shown to display bactericidal activity in particular against M.Tuberculosis.
 
Many published papers have pointed to EPX playing a role as a biomarker in asthma, as it is found at significant levels in active asthma patients. It is thought to contribute to airway dysfunction and the remodelling seen in asthma. It is a potent oxidant inducer in epithelial cells and is thought to be responsible for the prothrombotic and proinflammatory phenotypes exhibited by endothelial cells in hypereosinophilic syndrome. Autoantibodies to EPX have been found in patients with vasculitic and glomerular diseases, this interference with activity suggests the autoantibodies may be of pathogenetic importance. 

 
PDF-logo-dl Eosinopihil Peroxidase datasheet
Vasculitic and glomerular diseases
Eosinophil peroxidase is implicated in hereditary eosinophil peroxidase deficiency
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  • Carlson M.G. et al. (1985) Human eosinophil peroxidase: purification and characterization. J. Immunol. 134, 1875-9
  • Borelli, V. et al. (2003) Human eosinophil peroxidase induces surface alteration, killing and lysis of Mycobacterium tuberculosis.Infect. Immunol. 71, 605-13
  • Bjornsson, E. et al. (1996) Eosinophil peroxidase: a new serum marker of atopy and bronchial hyper-responsiveness. Respir. Med.90, 39-46
  • Sanz, M.L. eta al. (1997) serum eosinophil peroxidase (EPO) levels in asthmatic patients. Allergy 52, 417-22
  • Nair, P. et al. (2013) Eosinophil peroxidase in sputum represents a unique biomarker of airway eosinophilia. Allergy 68, 1177-84
  • Dolman, K.M. et al. (1993) A novel specificity of anticytoplasmic autoantibodies directed against eosinophil peroxidase. Clin. Exp.Immunol. 92, 58-64
  • Takiguchi, J. et al. (2005) Anti-eosinophil peroxidase antibodies detected in patients with primary biliary cirrhosis. Hepatol. Res. 32,33-7
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AROTEC Diagnostics
AROTEC have been producing and supplying premium reagents to the diagnostic industry since our incorporation in 1996
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