Native - Human Eosinophils
EPX, a heme-containing haloperoxidase, consists of a heavy chain of 50-57kDa and light chain 11-15kDa with a high content of both arginine and aspartic residues. Structurally related to myeloperoxidase, it is the most abundant granule protein in eosinophils. Granulocytes are known as early responders to microbial invasion leading to an inflammatory response. They have been shown to display bactericidal activity in particular against M.Tuberculosis.
Many published papers have pointed to EPX playing a role as a biomarker in asthma, as it is found at significant levels in active asthma patients. It is thought to contribute to airway dysfunction and the remodelling seen in asthma. It is a potent oxidant inducer in epithelial cells and is thought to be responsible for the prothrombotic and proinflammatory phenotypes exhibited by endothelial cells in hypereosinophilic syndrome. Autoantibodies to EPX have been found in patients with vasculitic and glomerular diseases, this interference with activity suggests the autoantibodies may be of pathogenetic importance.
Eosinopihil Peroxidase datasheet
Vasculitic and glomerular diseases
Eosinophil peroxidase is implicated in hereditary eosinophil peroxidase deficiency
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