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Ribosomal P

Native - Calf Thymus
US $520.00
Vial Size
rRNP antigen
Uniprot ID:  Q95140
mRNA RefSeq:  NM_001012682
Protein RefSeq:  NP_001012700
Anti-ribosomal P antibodies are considered to be specific for systemic lupus erythematosus (SLE), and their presence frequently correlates with disease activity, in particular psychotic depression, hepatitis, and nephritis. Although anti-ribosomal P antibodies have been reported to occur in patients with systemic sclerosis, this would appear to be rare and normally indicates an overlap with SLE.

The P proteins are three of approximately 80 proteins that make up the largest cytoplasmic ribonucleoprotein, the ribosome. Since ribosomes are assembled in the nucleoli, high titre anti-ribosomal P sera will show nucleolar as well as cytoplasmic immunofluorescent staining. The exact functions of the individual P proteins are not fully understood however studies suggest that they collectively comprise part of a functional GTPase domain necessary for the binding of factor-GTP complexes. This interaction results in catalysis of the appropriate step of the protein synthesis cycle (initiation, elongation or release).

The C-terminal 17 amino acids of all three P proteins are virtually identical and are highly conserved between species. Although the major autoantibody epitope on all three proteins is believed to be located within the C-terminal 22 amino acids, there is recent evidence that other individual P protein-specific epitopes occur.

The ribosomal P0, P1 and P2 proteins are all present in AROTEC’s ribosomal P antigen. The antigen typically exhibits a 260/280 nm absorbance ratio of >1.5, suggesting that a significant rRNA component is present. The sequences of the bovine P0 and P2 proteins have been determined, and found to be very homologous (>99%) to their human equivalents.  In particular the C-terminal 22 amino acids of both species were found to be identical.

PDF-logo-dl Ribosomal P datasheet
Systemic Lupus erythematosus
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  • Sturgill, P.H. et al. (1965) Arthritis Rheum. 8, 213
  • Schur, P.H. et al. (1967) Immunochemistry 4, 447
  • Elkon, K.B. et al. (1985) J. Exp. Med. 162, 459
  • Francoeur, A.-M. et al. (1985) J. Immunol. 135, 2378
  • Elkon, K.B. et al. (1992) Rheum. Dis. Clin. 18, 377
  • Teh, L.S. & Isenberg, D.A. (1994) Arthritis Rheum. 37, 307
  • Koren, E. et al. (1993) Arthritis Rheum. 36, 1325
  • Hulsey, M. et al. (1995) Clin. Immunol. Immunopathol. 74, 252
  • Arnett, F.C. & Reichlin, M. (1995), Am. J. Med. 99, 465
  • Martin, A.L. & Reichlin, M. (1996) Lupus 5, 22
  • Sato, T. et al. (1991) J. Rheumatol. 18, 1681
  • Fujimoto, M et al. (1996) J. Dermatol. 23, 33
  • Fujimoto, M. et al. (1995) Br. J. Rheumatol. 34, 908
  • Elkon, K.B. (1994) Man. Biol. Markers Dis. (Kluwer Acad. Publ.)B5/1-11
  • Chu, J.L. et a l. (1991) J. Exp. Med. 174, 507
  • Teh, L.S. et al. (1992) Br. J. Rheumatol. 32, 287
  • Elkon, K. et al. (1986) Proc. Natl. Acad. Sci. USA 83, 7419
  • Fabien, N. et al. (1999) J. Autoimmun. 13, 103
  • SWISS-PROT RLA0_BOVIN primary accession number Q95140 &RLA2_BOVIN primary accession number P42899
  • Rich, B.E. & Steitz, J.A. (1987) Mol. Cell Biol. 7, 4065

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AROTEC Diagnostics
AROTEC have been producing and supplying premium reagents to the diagnostic industry since our incorporation in 1996
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