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Anti-Myeloperoxidase IgG

Goat anti-Human antibody (Protein G purified)
Vial Size
Purification: Purified using Protein G affinity chromatography
Immunogen: Native myeloperoxidase antigen purified from human neutrophils
Applications: Immunocytochemistry, Western blot, sandwich ELISA
Myeloperoxidase levels have been reported to be of significance in artherosclerosis, myocardial infarction, atrial fibrillation, multiple sclerosis, Alzheimer's disease, lung cancer and transplant rejection. Autoantibodies to myeloperoxidase are known to occur in various types of systemic vasculitis.
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Klebanoff SJ (2005) Myeloperoxidase: friend and foe. J. Leukoc. Biol. 77: 598‐625
Klebanoff SJ et al. (2013) Myeloperoxidase: a front‐line defender against phagocytosed microroganisms. J. Leukoc. Biol. 93: 185‐98
Nussbaum C et al. (2013) Myeloperoxidase: a leukocyte‐derived protagonist of inflammation and cardiovascular disease. Antioxid. Redox. Signal. 18:
Zhang R et al (2001) Association between myeloperoxidase levels and risk of coronary artery disease. JAMA 286: 2136–42
Nahrendorf M et al. (2008) Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively
detects the antiinflammatory effects of atorvastatin on ischemia‐reperfusion injury. Circulation 117: 1153–60
Brennan ML et al. (2003) Prognostic value of myeloperoxidase in patients with chest pain. N Engl J Med 349: 1595–1604
Rudolph V et al. (2010) Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation. Nat Med 16: 470–4
Gray E et al. (2008) Elevated myeloperoxidase activity in white matter in multiple sclerosis. Neurosci Lett 444: 195–8
Reynolds WF et al. (1999) Myeloperoxidase polymorphism is associated with gender specific risk for Alzheimer’s disease. Exp Neurol 155: 31–41
Feyler A et al. (2002) Point: myeloperoxidase ‐463G –> a polymorphism and lung cancer risk. Cancer Epidemiol Biomark. Prev 11: 1550–4
Swirski FK et al. (2010) Myeloperoxidase‐rich Ly‐6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in
mice. J Clin Invest 120: 2627–34
Kallenberg CG (1998) Autoantibodies to myeloperoxidase: clinical and pathophysiological significance. J. Mol. Med. (Berl.) 76: 682‐7
Jayne D (2004) The clinical features and pathology of vasculitis associated with anti‐myeloperoxidase autoantibodies. Jpn. J. Infect. Dis. 57:S16‐7
Yamanishi Y et al. (2013) Clinical features of patients with anti‐neutrophil cytoplasmic autoantibodies targeting native myeloperoxidase antigen.
Mod. Rheumatol. 23: 963‐71

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AROTEC Diagnostics
AROTEC have been producing and supplying premium reagents to the diagnostic industry since our incorporation in 1996
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