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ATA02

ATA02

Annexin A3

Native - Human Neutrophils
US $364.00
Vial Size
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Annexin III
Annexin-3
35-alpha calcimedin
Inositol 1,2-cyclic phosphate 2-phosphohydrolase
Lipocortin III
Placental anticoagulent protein III
PAP-III
Uniprot ID:  P12429
mRNA RefSeq:  NM_005139
Protein RefSeq:  NP_005130
Annexins form a family of proteins that bind phospholipids in a calcium dependent manner with repeats of 70-80 amino acid domains that are highly conserved, with the different properties being conferred by the variable N-termini. Annexin III is expressed in differentiated cells of myeloid lineage which is expressed less ubiquitously than Annexin V.

Annexin III associates with cytoplasmic granules in both neutrophils and monocytes and it is suggested to be enzymatically active. It is thought to have prognostic value in a number of cancers including colorectal and upper tract urethral carcinoma. It may also play a specific role as a non-invasive marker for early detection of prostate cancer.

 
PDF-logo-dl Annexin A3 datasheet
Annexin A3 levels have been reported to be of clinical significance in prostate cancer, upper tract urethral carcinoma, colorectal cancer, breast cancer and lung adenocarcinoma
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  • Favier-Perron B et al. (1996) The high resolution crystal structure of human annexin III shows subtle differences with annexin V. Biochemistry 35:1740-4
  • Perron B et al. (1997) Can enzymatic activity, or otherwise, be inferred from structural studies of annexin III? J. Biol. Chem. 272:11321-6
  • Sopkova J et al. (2002) Ca2+ and membrane binding to annexin 3 modulate the structure and dynamics of its N terminus and domain III. Protein Sci.11:1613-25
  • Koellermann J et al. (2008) Expression and prognostic relevance of annexin A3 in prostate cancer. Eur. Urol. 54:1314-23S
  • chostak M et al. (2009) Annexin A3 in urine: a highly specific noninvasive marker for prostate cancer early detection. J. Urol. 181:343-53
  • Roobol MJ et al. (2011) Tumour markers in prostate cancer III: biomarkers in urine. Acta Oncol. 50:85-9
  • Liu YK et al. (2009) Quantitative proteome analysis reveals annexin A3 as a novel biomarker in lung adenocarcinoma. J. Pathol. 217:54-64
  • Zeng C et al. (2013) Annexin A3 is associated with a poor prognosis in breast cancer and participates in the modulation of apoptosis in vitro by affecting the Bcl-2/Bax balance. Exp. Mol. Pathol. 95:23-31
  • Wu N et al. (2013) The role of annexin A3 playing in cancers. Clin. Transl. Oncol. 15:106-10
  • Lu CM et al. (2014) A panel of tumor markers, calreticulin, annexin A2, and annexin A3 in upper tract urothelial carcinoma identified by proteomicand immunological analysis. BMC Cancer 23:363
  • Xie YQ et al. (2013) Prognostic value of Annexin A3 in human colorectal cancer and its correlation with hypoxia-inducible factor-1α. Oncol. Lett. 6:1631-35
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