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Native - Human Neutrophils
US $102.00
Vial Size
Uniprot ID:  P02788 (2 isoforms)
mRNA RefSeq:  NM_002343 NM_001199149
Protein RefSeq:  NP_001186078 NP_002334
Lactoferrin is an 80kDa iron binding glycoprotein produced by many exocrine glands. It is a major component of secondary granules in neutrophils. Lactoferrin displays diverse biological activities with key roles in microbicidal effects and activation of innate immune responses. The presence of lactoferrin in bodily fluids including the intestinal lumen is known to be proportional to the influx of neutrophils in that region and is therefore used as a reliable biomarker in inflammation related diseases and infections.
Recent studies have shown lactoferrrin to be a valuable marker when used in faecal assays. C.difficile infections, urinary tract infections, pouchitis and infectious diarrhoea are commonly tested for using assays targeting lactoferrin. It has also been reported to be found at higher levels in patients with Crohn’s disease in comparison to inflammatory bowel syndrome.
Lactoferrin autoantibodies have been detected in SLE and vasculitic diseases but specific pathogenic roles have yet to be determined and if any significance can be obtained from these results.  

PDF-logo-dl Lactoferrin datasheet
Inflammatory Bowel disease
Autoantibodies to lactoferrin have also been reported in:
Rheumatoid Arthritis
Systemic Lupus Erythematosus
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  • Legrand D et al. (2008) Lactoferrin structure and functions. Adv. Exp. Med. Biol. 606, 163-94
  • Brock JH (2002) The physiology of lactoferrin. Biochem. Cell Biol. 80, 1-6
  • Baker HM & Baker EN (2012) A structural perspective on lactoferrin function. Biochem. Cell Biol. 90, 320-8
  • Sugi K at al. (1996) Fecal lactoferrin as a marker for disease activity in inflammatory bowel disease: comparison with other neutrophil-derivedproteins. Am. J. Gastroenterol. 91, 927-34
  • Gonsalves S et al. (2013) Fecal lactoferrin: a noninvasive fecal biomarker for the diagnosis and surveillance of pouchitis. Dis. Colon Rectum 56, 733-7
  • Lourenco AG et al. (2013) Lactoferrin, a marker for periodontal disease. Curr. HIV Res. 11, 220-5
  • Pfefferkorn MD et al. (2010) Utility of fecal lactoferrin in identifying Crohn disease activity in children. J. Pediatr. Gastroenterol. Nutr. 51, 425-8
  • Chen CC et al. (2011) Usefulness of fecal lactoferrin in predicting and monitoring the clinical severity of infectious diarrhea. World J. Gastroenterol.17, 4218-24
  • Arao S et al. (1999) Measurement of urinary lactoferrin as a marker of urinary tract infection. J. Clin. Microbiol. 37, 553-7
  • Archbald-Pannone LR (2014) Quantitative fecal lactoferrin as a biomarker for severe Clostridium difficile infection, stool toxin and 027 infection. Eur.J. Microbiol. Infect. Dis. 32, 1517-23
  • Coremans, IE et al. (1993) Anti-lactoferrin antibodies in patients with rheumatoid arthritis with vasculitis. Adv. Exp. Med. Biol. 336, 357-62
  • Caccaco D et al. (2005) Anti-lactoferrin antibodies in systemic lupus erythematosus: isotypes and clinical correlates. Clin. Rheumatol. 24, 381-7
  • Teegen B et al. (2009) DNA-bound lactoferrin is the major target for antineutrophil perinuclear cytoplasmic antibodies in ulcerative colitis. Ann. NYAcad. Sci. 1173, 161-5

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