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ATL03

ATL03

Lysozyme

Native - Human Neutrophils
US $100.00
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LYZ
Uniprot ID:  P61626
mRNA RefSeq:  NM_000239
Protein RefSeq:  NP_000230
Lysozyme catalyzes the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in peptidoglycan. A very basic enzyme, it is well known for its ability to hydrolize the cell wall of bacteria. Lysozyme consists of 129 amino acids with a molecular weight of 15kDa.
 
It is been found at elevated levels in cerebrospinal fluid in bacterial meningitis and also in colitis. Differential up-regulation of lysozyme in different cell types may offer diagnostic value in collagenous and lymphocytic colitis.

 
PDF-logo-dl Lysozyme datasheet
Primary Sclerosing Cholangitis
Crohn's disease
Ulcerative Colitis
Lysozyme is implicated in hereditary systemic amyloidosis
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  • McKenzie H.A. & White F.H. (1991) Lysozyme and alpha-lactalbumin: structure, function and interrelationships. Adv. Protein Chem. 41:173-315
  • Yoshimura K. et al. (1988) Human lysozyme: sequencing of cDNA, and expression and secretion by Saccharomyces cerevisiae. Biochem. Biophys.Res. Comm. 150:794-801
  • Jolles P. (1996) Lysozymes: model enzymes in biochemistry and biology. Boston: Birkhauser Verlag BaselMerlini G. & Bellotti V. (2005) Lysozyme: a paradigmatic molecule for the investigation of protein structure, function and misfolding. Clin. Chim.Acta 357:268-72
  • Hoijer M.A. et al. (1998) Differences in N-acetylmuramyl-L-alanine amidase and lysozyme in serum and cerebrospinal fluid of patients with bacterialmeningitis. J. Infect. Dis. 177:102-6
  • Tomita H. et al. (1999) Serum lysozyme levels and clinical features of sarcoidosis. Lung 177:161-7
  • Torsteindottir I. et al. (1999) Serum lysozyme: a potential marker of monocyte/macrophage activity in rheumatoid arthritis. Rheumatol. 38:1249-54
  • Rubio C.A. (2011) Lysozyme expression in microscopic colitis. J. Clin. Pathol. 64:510-5
  • Schroeder S. et al. (2000) Lysozyme in ventriculitis: a marker for diagnosis and disease progression. J. Neurol. Neurosurg. Psychiatry 69:696-7
  • Rubio C.A. (2014) The natural antimicrobial enzyme lysozyme is up-regulated in gastrointestinal inflammatory conditions. Pathogens 3:73-92
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