Eosinophil Cationic Protein (ECP)

Native - Human Eosinophils

Alternate Names:

ECP | Ribonuclease 3 | RNase 3

Uniprot IDs:	P12724
mRNA RefSeq:	NM_002935.2
Protein RefSeq:	NM_002926.2

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Product Information

Eosinophil Cationic Protein (ECP) is a cytotoxic granule protein released by activated eosinophils, playing a crucial role in the body’s immune response to inflammation. As an essential member of the immune system, ECP is involved in both allergic and autoimmune diseases, where it contributes to immune-mediated tissue damage. Its presence and levels in the body offer insight into immune activity, making ECP a valuable biomarker in the clinical diagnosis and monitoring of various inflammatory conditions.

In allergic diseases, such as asthma and atopic dermatitis, elevated ECP levels reflect increased eosinophil activation and are associated with the severity of inflammation. In asthma, for example, higher levels of ECP correlate directly with airway inflammation and hyperresponsiveness, leading to a better understanding of disease activity and the effectiveness of treatment interventions. ECP’s role in allergic conditions underscores its utility in tracking inflammatory status and guiding personalized treatment.

In autoimmune conditions, ECP is implicated in disease processes beyond typical allergic responses. Elevated ECP levels are commonly observed in chronic urticaria, where it contributes to mast cell activation and the release of histamine, resulting in symptoms like hives and angioedema. Additionally, ECP is linked to other autoimmune diseases, where its presence provides insight into disease activity and progression, thus expanding its diagnostic significance.

Measuring ECP levels offers clinicians a reliable tool for assessing immune activity in both allergic and autoimmune conditions. As a key indicator of eosinophil activity, ECP provides critical data for evaluating disease severity, monitoring treatment responses, and adjusting therapeutic approaches. Its role as a biomarker makes ECP indispensable in the diagnosis, monitoring, and management of immune-mediated inflammatory diseases.