Publications
AROTEC products referenced in published research
(2025)
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Autoimmunity, 58:1, 2441992.
Clinical correlations of serum anti-dsDNA immunoglobulin subfamilies in patients with systemic lupus erythematosus (SLE)
(2025)
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Lupus Science & Medicine 2025 doi:10.1136/ lupus-2024-001418
Neutrophil gelatinase-associated lipocalin (NGAL) in lupus nephritis and beyond
(2024)
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J. Autoimmun. Jun:146:103245.
CD72 is an inhibitory pattern recognition receptor that recognizes ribosomes and suppresses production of anti-ribosome autoantibody
(2024)
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Arthritis Rheumatol. 76(3):411-420.
Prospective Evaluation of High Titer Autoantibodies and Fetal Home Monitoring in the Detection of Atrioventricular Block Among Anti-SSA/Ro Pregnancies
(2024)
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Front Immunol. 5:13:988125.
Autoantibodies elicited with SARS-CoV-2 infection are linked to alterations in double negative B cells
(2024)
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Sci Transl Med. Jul 3;16(754):eadl3848.
Lupus IgA1 autoantibodies synergize with IgG to enhance plasmacytoid dendritic cell responses to RNA-containing immune complexes
(2024)
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Proc Natl Acad Sci U S A. Jan 30;121(5):e2304020121.
Targeted checkpoint control of B cells undergoing positive selection in germinal centers by follicular regulatory T cells
(2024)
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J Biol Chem. Aug;300(8):107533. doi: 10.1016/j.jbc.2024.107533.
Exogenous serpin B1 restricts immune complex-mediated NET formation via inhibition of a chymotrypsin-like protease and enhances microbial phagocytosis
(2023)
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J Autoimmun. Feb:135:102998.
Conformational state of C-reactive protein is critical for reducing immune complex-triggered type I interferon response: Implications for pathogenic mechanisms in autoimmune diseases imprinted by type I interferon gene dysregulation
(2023)
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Front Immunol.
Isolated anti-Ro52 identifies a severe subset of Sjögren’s syndrome patients
(2023)
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Elife
Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells
(2023)
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J. Immunol.
Genetic Reduction of IRF5 Expression after Disease Initiation Reduces Disease in a Mouse Lupus Model by Impacting Systemic and End-Organ Pathogenic Pathways
(2023)
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EBioMedicine. Dec:98:104878.
Interim results from a phase I randomized, placebo-controlled trial of novel SARS-CoV-2 beta variant receptor-binding domain recombinant protein and mRNA vaccines as a 4th dose booster
(2022)
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Am J Obstet Gynecol.
Reducing the burden of surveillance in pregnant women with no history of fetal atrioventricular block using the negative predictive value of anti-Ro/SSA antibody titers
(2022)
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Diagnostics (Basel). Nov 3;12(11):2682
PR3-ANCAs Detected by Third-Generation ELISA Predicts Severe Disease and Poor Survival in Primary Sclerosing Cholangitis
(2022)
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Immunology. Jan;165(1):122-140.
Haemoglobin drives inflammation and initiates antigen spread and nephritis in lupus
(2022)
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Front Immunol. Nov 24:13:1051779.
A pregnancy hormone-cell death link promotes enhanced lupus-specific immunological effects
(2022)
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J Exp Med. Jul 4;219(7):e20220047.
CXCR4+ Treg cells control serum IgM levels and natural IgM autoantibody production by B-1 cells in the bone marrow
(2022)
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Immunity. Jul 12;55(7):1216-1233.e9.
Viral infection engenders bona fide and bystander subsets of lung-resident memory B cells through a permissive mechanism
(2022)
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J Exp Med. Jun 6;219(6):e20212553. doi: 10.1084/jem.20212553.
SARS-CoV-2 infection relaxes peripheral B cell tolerance
(2021)
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Front Immunol. May 24:12:676010
TLR7 Signaling Drives the Development of Sjögren’s Syndrome
(2021)
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Immunohorizons. Jan 14;5(1):2-15.
STAT4 Is Largely Dispensable for Systemic Lupus Erythematosus-like Autoimmune- and Foreign Antigen-Driven Antibody-Forming Cell, Germinal Center, and Follicular Th Cell Responses
(2021)
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Front Immunol. Jun 30:12:688753
Comparison of Surrogate Markers of the Type I Interferon Response and Their Ability to Mirror Disease Activity in Systemic Lupus Erythematosus
(2021)
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J Immunol. Jun 15;206(12):2803-2818.
Context-Dependent miR-21 Regulation of TLR7-Mediated Autoimmune and Foreign Antigen-Driven Antibody-Forming Cell and Germinal Center Responses
(2021)
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JCI Insight. Aug 9;6(15):e141395
Monoallelic IRF5 deficiency in B cells prevents murine lupus
(2021)
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Clin Transl Immunology. Jun 14;10(6):e1295.
Next-generation Bruton’s tyrosine kinase inhibitor BIIB091 selectively and potently inhibits B cell and Fc receptor signaling and downstream functions in B cells and myeloid cells
(2021)
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Clin Exp Immunol. Jan;203(1):13-21.
Identification of a unique anti-Ro60 subset with restricted serological and molecular profiles
(2021)
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J Immunol. Nov 1;207(9):2217-2222.
Cutting Edge: A Threshold of B Cell Costimulatory Signals Is Required for Spontaneous Germinal Center Formation in Autoimmunity
(2020)
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J Immunol.
Type II but Not Type I IFN Signaling Is Indispensable for TLR7-Promoted Development of Autoreactive B Cells and Systemic Autoimmunity.
(2020)
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J Immunol. May 15;204(10):2641-2650.
Serine Phosphorylation of the STAT1 Transactivation Domain Promotes Autoreactive B Cell and Systemic Autoimmunity Development
(2019)
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J Immunol.
Lupus-Associated Immune Complexes Activate Human Neutrophils in an FcγRIIA-Dependent but TLR-Independent Response.
(2019)
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Front Immunol.
High TLR7 Expression Drives the Expansion of CD19+CD24hiCD38hi Transitional B Cells and Autoantibody Production in SLE Patients.
(2019)
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J Immunol.
Differences in Self-Recognition between Secreted Antibody and Membrane-Bound B Cell Antigen Receptor.
(2019)
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J Immunol.
Functional Characterization of CD11c+ Age-Associated B Cells as Memory B Cells.
(2019)
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Autoimmunity.
Autoantigen-specific B cells and plasma cells are prominent in areas of fatty infiltration in salivary glands of patients with primary Sjögren’s syndrome.
(2019)
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Arthritis Rheumatol.
Macrophage Migration Inhibitory Factor Regulates U1 Small Nuclear RNP Immune Complex-Mediated Activation of the NLRP3 Inflammasome.
(2019)
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Biosens Bioelectron
Label-free electrochemical impedimetric immunosensor for sensitive detection of IgM rheumatoid factor in human serum.
(2018)
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Int Immunopharmacol.
MiR-155 controls follicular Treg cell-mediated humoral autoimmune intestinal injury by inhibiting CTLA-4 expression.
(2018)
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Exp Dermatol.
Mechanisms of Pathogenic Effects of Eosinophil Cationic Protein and Eosinophil Derived Neurotoxin on Human Keratinocytes.
(2018)
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Clin Exp Immunol.
Precipitating anti-dsDNA peptide repertoires in lupus.
(2018)
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Nat Commun.
Galectin-3 deficiency drives lupus-like disease by promoting spontaneous germinal centers formation via IFN-γ.
(2018)
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Kidney Int. 94(4):728-740
TACI deletion protects against progressive murine lupus nephritis induced by BAFF overexpression.
(2018)
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Clin Chem Lab Med.
Detection of autoantibodies to the p200-epitope of SSA/Ro52 antigen. A comparison of two laboratory assays.
(2018)
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Front. Immunol.
Immune tolerance to apoptotic self is mediated primarily by regulatory B1a Cells.
(2017)
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Clin Exp Immunol. 187(3):353-36
Innate and humoral recognition of the products of cell death: differential antigenicity and immunogenicity in lupus.
(2017)
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J Exp. Med.
B cell-derived IL-6 initiates spontaneous germinal center formation during systemic autoimmunity.
(2017)
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Clin. Immunol.
Autoantibodies of IgM and IgG classes show differences in recognition of multiple autoantigens in chronic obstructive pulmonary disease.
(2017)
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J Immunol. 10.4049
The Autoimmune Risk Variant PTPN22 C1858T Alters B Cell Tolerance at Discrete Checkpoints and Differentially Shapes the Naive Repertoire.
(2017)
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J Immunol Methods. 448:34-43
Photonic ring resonance is a versatile platform for performing multiplex immunoassays in real time.
(2017)
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Front Immunol. 8:732
Oxidized Hemoglobin Is Antigenic and Immunogenic in Lupus.
(2017)
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Front Immunol. 8:594
Relevance of CD6-Mediated Interactions in the Regulation of Peripheral T-Cell Responses and Tolerance.
(2017)
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Ann Rheum Dis. 76(7):1176-1183
Carbamylation of vimentin is inducible by smoking and represents an independent autoantigen in rheumatoid arthritis.
(2017)
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J Autoimmun. 79:99-104
Ro52 autoantibodies arise from self-reactive progenitors in a mother of a child with neonatal lupus.
(2017)
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J Exp Med. 214(7):2103-2119
TLR7/8 activation in neutrophils impairs immune complex phagocytosis through shedding of FcgRIIA.
(2017)
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JCI Insight.
DOCK8 regulates fitness and function of regulatory T cells through modulation of IL-2 signaling.
(2016)
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Kidney Int. 89(1):158-66
Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus.
(2016)
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J Exp Med. 213(5):733-50
B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6.
(2016)
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Nat Immunol. 17(2): 196-203
Self-reactive IgE exacerbates interferon responses associated with autoimmunity.
(2016)
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Immunity. 44(6):1350-64
Store-Operated Ca(2+) Entry in Follicular T Cells Controls Humoral Immune Responses and Autoimmunity.
(2016)
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J Immunol. 197(1):27-41
Regulatory T Cells Control Th2-Dominant Murine Autoimmune Gastritis.
(2016)
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JEM. October 17, 2016 Volume 213, No. 11
CD72 negatively regulates B lymphocyte responses to the lupus-related endogenous toll-like receptor 7 ligand Sm/RNP.
(2016)
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Arthritis Res Ther. 18(1):111
Antiphospholipid antibodies detected by line immunoassay differentiate among patients with antiphospholipid syndrome, with infections and asymptomatic carriers.
(2016)
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Clin Chem Acta. 1;456:1-6
A novel sol particle immunoassay for fecal calprotectin in inflammatory bowel disease patients.
(2016)
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J Autoimmun. 67:36-45
Targeting downstream transcription factors and epigenetic modifications following Toll-like receptor 7/8 ligation to forestall tissue injury in anti-Ro60 associated heart block.
(2016)
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Clin Immunol. S1521-6616(16)30359
IgV peptide mapping of native Ro60 autoantibody proteomes in primary Sjögren’s syndrome reveals molecular markers of Ro/La diversification.
(2016)
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Clin Exp Immunol. 184(1):29-35
Lupus anti-ribosomal P autoantibody proteomes express convergent biclonal signatures.
(2016)
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J Immunol. 125(4):1488-94
C1q Modulates the Response to TLR7 Stimulation by Pristane-Primed Macrophages: Implications for Pristane-Induced Lupus.
(2016)
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Nat Med. 22(2):146-53
Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like diseases.
(2016)
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Autoimmun Rev. S1568-9972(16)30001-5
Secreted autoantibody repertoires in Sjögren’s syndrome and systemic lupus erythematosus: A proteomic approach.
(2016)
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Methods Mol Biol. 1390:249-72
Toll-Like Receptor-Dependent Immune Complex Activation of B Cells and Dendritic Cells.
(2016)
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PLoS One. 11(7):e0158641
Humoral Dysregulation Associated with Increased Systemic Inflammation among Injection Heroin Users.
(2015)
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Blood. 125(10):1578-88
Two types of BCR interactions are positively selected during leukemia development in the Eμ-TCL1 transgenic mouse model of CLL.
(2015)
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J Exp Med. 212(10):1663-77
Altered BCR and TLR signals promote enhanced positive selection of autoreactive transitional B cells in Wiskott-Aldrich syndrome.
(2015)
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J Autoimmun. 57:77-81
Serum SmD autoantibody proteomes are clonally restricted and share variable-region peptides.
(2015)
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Transfusion. Epub
Plasma exchange effectively removes 52- and 60-kDa anti-Ro/SSA and anti-La/SSB antibodies in pregnant women with congenital heart block.
(2015)
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J Immunol. 194(1):101-12
Inhibition of type 4 cyclic nucleotide phosphodiesterase blocks intracellular TLR signaling in chronic lymphocytic leukemia and normal hematopoietic cells.
(2015)
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J Autoimmun. 61:9-16
Deleting the BAFF receptor TACI protects against systemic lupus erythematosus without extensive reduction of B cell numbers.
(2015)
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J Am Heart Assoc.
Reactivity to the p305 Epitope of the α1G T-Type Calcium Channel and Autoimmune-Associated Congenital Heart Block.
(2014)
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J Immunol. 192(10):4525-32
Opposing impact of B cell-intrinsic TLR7 and TLR9 signals on autoantibody repertoire and systemic inflammation.
(2014)
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Clin Exp Immunol. 175(1):32-40
Effects of adjuvants for human use in systemic lupus erythematosus (SLE)-prone (New Zealand black/New Zealand white) F1 mice.
(2014)
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Arthritis Res Ther. 16(1):R48
Serum nitrated nucleosome levels in patients with systemic lupus erythematosus: a retrospective longitudinal cohort study.
(2014)
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Clin Biochem. 47(10-11):901-8
Prostate cancer biomarker annexin A3 detected in urines obtained following digital rectal examination presents antigenic variability.
(2014)
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Methods Mol Biol. 1169:143-58
Evaluating the role of nucleic acid antigens in murine models of systemic lupus erythematosus.
(2013)
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Pathology. 45(5):525-7
Biotinylation of ANCA target antigen improves assay performance for PR3-ELISA but not MPO-ELISA.
(2013)
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Clin Exp Immunol. 172(2):228-37
Ro52- and Ro60-specific B cell pattern in the salivary glands of patients with primary Sjögren’s syndrome.
(2013)
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J Exp Med. 210(12):2773-89
Overexpression of TLR7 promotes cell-intrinsic expansion and autoantibody production by transitional T1 B cells.
(2013)
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Clin Exp Immunol. 174(2):237-44
An immunodominant La/SSB autoantibody proteome derives from public clonotypes.
(2013)
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Arthritis Rheum. 65(10):2713-23
Contrasting mechanisms of interferon-α inhibition by intravenous immunoglobulin after induction by immune complexes versus Toll-like receptor agonists.
(2013)
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PLoS One. 8(9):e72401
Application of fluorescent monocytes for probing immune complexes on antigen microarrays.
(2013)
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Arthritis Res Ther. 15(5):R114
In vitro suppression of immune responses using monocyte-derived tolerogenic dendritic cells from patients with primary Sjögren’s syndrome.
(2013)
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Front Immunol. 4:225
Ly9 (CD229) Cell-Surface Receptor is Crucial for the Development of Spontaneous Autoantibody Production to Nuclear Antigens.
(2012)
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J Immunol. 188(10):4769-75
U1-small nuclear ribonucleoprotein activates the NLRP3 inflammasome in human monocytes.
(2012)
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J Autoimmun. 39(4):466-70
Secreted human Ro52 autoantibody proteomes express a restricted set of public clonotypes.
(2012)
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J Proteomics. 75(5):1472-85
Proteinase 3 carries small unusual carbohydrates and associates with αlpha-defensins.
(2012)
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Am J Physiol Gastrointest Liver Physiol. 302(1):G105-15
Spontaneous autoimmune gastritis and hypochlorhydria are manifest in the ileitis-prone SAMP1/YitFcs mice.
(2011)
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J Clin Pathol. 64(5):426-9
Streptokinase antibodies in patients presenting with acute coronary syndrome in three rural New Zealand populations.
(2011)
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Immunol Lett. 137(1-2):62-9
Transgenic expression of bovine neonatal Fc receptor in mice boosts immune response and improves hybridoma production efficiency without any sign of autoimmunity.
(2011)
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Arthritis Rheum. 63(11):3477-86
Molecular signature of a public clonotypic autoantibody in primary Sjögren’s syndrome: a “forbidden” clone in systemic autoimmunity.
(2011)
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Biochem Soc Trans. 39(4):1006-11
The BPI-like/PLUNC family proteins in cattle.
(2010)
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J Autoimmun. 35(4):291-8
TLR9 and TLR4 are required for the development of autoimmunity and lupus nephritis in pristane nephropathy.
(2010)
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Transplantation. 89(9):1071-8
Urinary soluble HLA-DR is a potential biomarker for acute renal transplant rejection.
(2010)
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J Clin Invest. 120(10):3651-62
TLR8 deficiency leads to autoimmunity in mice.
(2010)
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J Immunol. 185(8):4738-49
C1q deficiency leads to the defective suppression of IFN-alpha in response to nucleoprotein containing immune complexes.
(2009)
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Arthritis Rheum. 60(4):1096-10
Interferon-alpha treatment of female (NZW x BXSB)F(1) mice mimics some but not all features associated with the Yaa mutation.
(2009)
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Clin Chem. 55(5):978-85
New ELISA for detecting primary biliary cirrhosis-specific antimitochondrial antibodies.
(2009)
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Methods Mol Biol. 517:363-80
Toll-like receptor-dependent immune complex activation of B cells and dendritic cells.
(2009)
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J Immunol. 182(2):1192-201
Potent induction of IFN-alpha and chemokines by autoantibodies in the cerebrospinal fluid of patients with neuropsychiatric lupus.
(2009)
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Genes Immun. 10(1):47-55
A lupus-susceptibility C57BL/6 locus on chromosome 3 (Sle18) contributes to autoantibody production in 129 mice.
(2009)
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Ann N Y Acad Sci. 1173:137-45
Possible involvement of chemokine-induced platelet activation in thrombophilic diathesis of antiphospholipid syndrome.
(2008)
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Clin Chem. 54(5):883-90
Screening autoantibody profiles in systemic rheumatic disease with a diagnostic protein microarray that uses a filtration-assisted nanodot array luminometric immunoassay (NALIA).
(2008)
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Arthritis Rheum. 58(9):2824-34
Prevention of murine antiphospholipid syndrome by BAFF blockade.
(2008)
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Arthritis Rheum. 58(4):1125-9
A B cell apotope of Ro 60 in systemic lupus erythematosus.
(2008)
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Arthritis Rheum. 58(7):2163-73
Induction of interferon-alpha by scleroderma sera containing autoantibodies to topoisomerase I: association of higher interferon-alpha activity with lung fibrosis.
(2008)
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PLoS One. 3(8):e3033
Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease.
(2005)
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J Exp Med. 202(9):1171-7
RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.
(2005)
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Clin Chem. 51(6):1029-31
Relative quantification of experimental data from antigen particle arrays.
(2005)
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Am J Pathol. 166(6):1851-60
Autoantibodies to vascular smooth muscle are pathogenic for vasculitis.
(2005)
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Clin Exp Immunol. 141(1):155-64
Major immunoreactive domains of human ribosomal P proteins lie N-terminal to a homologous C-22 sequence: application to a novel ELISA for systemic lupus erythematosus.
(2005)
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J Immunol Methods. 302(1-2):1-12