icon lock Secure Shipping Worldwide
cart Shopping Cart Cart (0)

Coeliac Disease

CD is a chronic gastrointestinal disorder caused by an abnormal immune response to gluten containing cereals such as wheat, rye and barley. About 1% of the population is thought to have coeliac disease. The disease is characterised by the flattening of the small bowel mucosa. Certain HLA genotypes (HLA-DQ2,HLA–DQ8) are required for the development of CD. This information can be used diagnostically as the absence of these HLA genotypes virtually rules out the presence of CD.

Diagnosis of coeliac disease involves serological tests for the presence of anti-tissue transglutaminase (tTG) and anti- deamidated gliadin peptide (DGP) antibodies with tissue transglutaminase being the autoantigen target. Anti-tTG antibodies recognise the same antigen as anti-endomysial antibodies (EMA). A deficiency in IgA can also be seen in a small percentage of patients suffering from coeliac disease making IgA based serology unreliable. A duodenal biopsy is generally performed to confirm coeliac disease and its severity.

Dieterich et al, Nat Med 1997 3:797-801
Tonutti et al, J Clin Pathol 2003 56:389-93
Qiao et al, J Immunol 2005 175:254-61
Koning F, Gastroenterology 2005 129:1294-301
Rostom et al, Gastroenterology 2005 128:S38-46
McPherson RA, J Clin Lab Anal. 2001 15:105-107
Tissue Transglutaminase

Tissue Transglutaminase

AROTEC Diagnostics
AROTEC have been producing and supplying premium reagents to the diagnostic industry since our incorporation in 1996
Read More
Contact Us


+64 4569 0361

207 Gracefield Road,
Lower Hutt,