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Pernicious Anaemia

Autoimmune gastritis is a pathological lesion that may eventuate in the development of pernicious anaemia. Generally autoantibodies are found circulating against parietal cell H/K-ATPase which is the primary diagnostic marker for gastritis. H/K-ATPase is the most abundant membrane protein of the canicular and tubovesicular membranes of parietal cells and is responsible for the acidification of the stomach. Autoantibodies to intrinsic factor can also be detected.
Vitamin B12 deficiencies are also indicative of this disease as autoantibodies to intrinsic factor inhibit the binding to vitamin B12 complex thus stopping its uptake within the ileum.

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Toh BH, Sentry JW and Alderuccio F, Immunol. Today 2000 21:348-54
D’Elios et al, Gastroenterology 2001 120:377-86
Hershko et al, Blood 2006 107:1673-9
Burman et al, J. Gastroenterology 1991 26:207-14
Parietal cell antigen (H/K-ATPase)

Parietal cell antigen (H/K-ATPase)

Native - Porcine Gastric Mucosa
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