icon lock Secure Shipping Worldwide
cart Shopping Cart Cart (0)
Select Currency:

ANCA Associated Diseases/Vasculitis

ANCA-associated vasculitides include granulomatosis with polyangiitis (GPA) formerly known as Wegener’s granulomatosis, microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EPA) formerly known as Churg-Strauss syndrome (CSS).

They are characterised by an interaction of anti-neutrophil cytoplasm autoantibodies (ANCA) with neutrophils which may be important in initiating vascular injury. Vasculitis is the inflammation of vessel walls and can lead to fibrosis, necrosis or thrombosis. This can result in damage to the body’s organs. Some other examples of vasculitis would be Kawasaki’s disease and Giant cell arteritis, with smaller vessels being affected by GPA and MPA.

Myeloperoxidase (MPO) has been identified as the main target antigen in MPA associated
ANCAs and proteinase 3 (PR3) in GPA. MPO antibodies produce a perinuclear (pANCA) pattern and PR3 antibodies a granular cytoplasmic (cANCA) pattern when performing IIF.

EIAs using MPO and PR3 as antigens are generally the most commonly performed assays alongside IIF. Lactoferrin, bactericidal/permeability increasing protein (BPI) and cathepsin G antibodies have also been reported to possibly play a role in vasculitis. These could be potential markers but further research is needed to determine their diagnostic value.

References:
Taylor et al, Clin Exp Immunol 2007 150(1): 42-48
Kida et al, Mod Rheumatol. 2011 21(1):43-50
Falk RJ and Jennette JC, N Engl J Med 1988 318:1651-1657
Choi et al, Arthritis Rheum 2000 43:405-413
Jenne et al, Nature 1990 346:520
Watts et al, Rheumatol 198 25:920-4
Tidman et al, J Intern Med 1998 244:138-41
Sort by:
Proteinase 3 (cANCA)

Proteinase 3 (cANCA)

ATP02
Native - Human Neutrophils
US $528.00
Amount
Qty.
Myeloperoxidase (pANCA)

Myeloperoxidase (pANCA)

ATM01
Native - Human Neutrophils
US $171.00
Amount
Qty.
Azurocidin

Azurocidin

ATA01
Native- Human Neutrophils
US $239.00
Amount
Qty.
BPI

BPI

ATB01
Native - Human Neutrophils
US $557.00
Amount
Qty.
Cathepsin G

Cathepsin G

ATC01
Native - Human Neutrophils
US $161.00
Amount
Qty.
Eosinophil Peroxidase (EPX)

Eosinophil Peroxidase (EPX)

ATE02
Native - Human Eosinophils
US $430.00
Amount
Qty.
Lactoferrin

Lactoferrin

ATL02
Native - Human Neutrophils
US $96.00
Amount
Qty.
Lysozyme

Lysozyme

ATL03
Native - Human Neutrophils
US $96.00
Amount
Qty.
AROTEC Diagnostics
AROTEC have been producing and supplying premium reagents to the diagnostic industry since our incorporation in 1996
Read More
   
Contact Us

info@arodia.com

+64 4569 0361

207 Gracefield Road,
Lower Hutt, 
Wellington