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ATC04

ATC04

Calprotectin

Native - Human Leukocytes
US $478.00
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Protein S100
Calgranulin
Migration inhibitory factor-related protein (MRP)
Uniprot ID:  P06702  P05109
mRNA RefSeq:  NM_002965 NM_002964
Protein RefSeq:  NP_002956 NP_002955
Calprotectin is an important calcium signalling protein involved in wound healing. A complex of both MRP14 and MRP8, calprotectin plays a role in vascular inflammation and leukocyte recruitment. The complex is a calcium and zinc- binding protein that represents 60% of cytosolic proteins of granulocytes. Classed as a damage associated molecular pattern marker it displays antimicrobial protective properties.

Extracellular release of calprotectin during cell damage/stress can be used as a marker for intestinal inflammation. There is growing evidence that faecal calprotectin correlates with mucosal disease activity which can be utilised as a monitoring response to relapse and treatments in inflammatory bowel disease. Measuring the concentration of calprotectin in faeces is an indirect measure of neutrophil infiltrate in the bowel mucosa.

AROTEC Diagnostics' Calprotectin is seen as a ~48kDa heterotetramer based on the size-exclusion profile observed.

 
PDF-logo-dl Calprotectin datasheet
Inflammatory bowel disease (IBD)
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  • Kerkhoff C, Klempt M, Sorg C. Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9). Biochim. Biophys.Acta 1998, 1448:200-211
  • Gebhardt C, Nemeth J, Angel P, Hess J. S100A8 and S100A9 in inflammation and cancer. Biochem. Pharmacol. 2006, 72:1622-1631
  • Korndörfer IP, Brueckner F, Skerra A. The crystal structure of the human (S100A8/S100A9)2 heterotetramer, calprotectin, illustrates how conformational changes of interacting alpha-helices can determine specific association of two EF-hand proteins. J. Mol. Biol.2007, 370:887-898
  • Sherwood RA. Faecal markers of gastrointestinal inflammation. J. Clin. Pathol. 2012, 64:981-985
  • Smith LA, Gaya DR. Utility of calprotectin analysis in adult inflammatory bowel disease. World J. Gastroenterol. 2012, 18:6782-6789
  • Burri, E and Beglinger C. Faecal calprotection - a useful tool in the management of inflammatory bowel disease. Swiss Med. Wkly.2012, 142:w13557
  • Lewis JD. The utility of biomarkers in the diagnosis and therapy of inflammatory bowel disease. Gastroenterology 2011, 140:1817-1826
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AROTEC Diagnostics
AROTEC have been producing and supplying premium reagents to the diagnostic industry since our incorporation in 1996
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