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ATR02

ATR02

Ro(SSA)

Native - Calf Thymus
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Ro RNP
SSA antigen
Ro60 antigen
Sjögren's syndrome antigen A
Uniprot ID:  F1MIZ7
mRNA RefSeq:  NM_001206183
Protein RefSeq:  NP_001193112
Autoantibodies to the Ro(SSA) antigen are one of the most frequent serological markers of autoimmunity in rheumatic diseases. They are present in the serum of 50-80% of patients with Sjögren’s syndrome, 30-40% of patients with systemic lupus erythematosus (SLE), and 3-5% of patients with rheumatoid arthritis (RA). Ro(SSA) autoantibodies have also been reported in Sjögren’s syndrome-lupus overlap disease, subacute cutaneous lupus erythematosus, lupus with complement component deficiencies, neonatal lupus syndrome, multiple myeloma, polymyositis, progressive systemic sclerosis and primary biliary cirrhosis.

The incidence of anti-Ro (SSA) antibodies in the population of normal women of reproductive age is in the order of 1%. The presence of anti-La (SSB) autoantibodies usually coincides with the presence of anti-Ro (SSA).

Ro(SSA) antibodies target protein antigens associated with small RNA molecules known as hY-RNAs. These protein-RNA complexes are referred to as Ro-ribonucleoproteins (Ro-RNPs) and their biological function has yet to be elucidated. It is generally acknowledged that a 60kDa protein (Ro60) intimately associated with Ro-RNP constitutes the major Ro(SSA) antigen. The binding of autoantibodies to Ro60 is heterogenous: some sera recognise both the native and denatured antigen while others recognise the native antigen conformation only. The association of a second putative Ro(SSA) antigen of 52kDa (Ro52) with Ro-RNP remains unclear.

Although it has been proposed that Ro52 may be indirectly associated with Ro-RNP through Ro60, it has been conversely demonstrated that Ro52 does not copurify with Ro-RNPs during chromatographic separation. Furthermore true monospecific anti-Ro52 sera are known to be rare, they do not display a typical Ro(SSA) immunofluorescence pattern and are negative in immunodiffusion.

 
PDF-logo-dl Ro (SSA) datasheet
Sjögren's syndrome
Systemic Lupus Erythematosus
Rheumatoid Arthritis
Neonatal Lupus Syndrome
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  • Tan, E.M. (1989) Adv. Immunol. 44, 93
  • McCauliffe, D.P. & Sontheimer, R.D. (1993) J. Inv. Dermatol. 100, 73
  • Harley, J.B. et al. (1986) Arthritis Rheum. 29, 196
  • Reichlin, M. (1986) J. Clin. Immunol. 6, 339
  • Boire, G. et al. (1993) J. Rheumatol. 20, 1654
  • Harley, J.B. et al. (1992) Rheum. Dis. Clin. N. America 18, 337
  • Calmes, M. & Bartholomew, B.A. (1985) J. Clin. Pathol. 38, 73
  • Taylor, P.V. et al. (1988) Br. J. Rheumatol. 27, 128
  • Craft, J.E. & Hardin, J.A. (1987) J. Rheumatol. 14 S13, 106
  • St. Clair, E.W. (1992) Rheum. Dis. Clin. N. America 18, 359
  • Hendrick, J.P. et al. (1981) Mol. Cell Biol. 1, 1138
  • Wolin, S.L. et al. (1984) 81, 1996
  • Chan, E.K.L. & Buyon, J.P. (1994) Man. Biol. Markers Dis.(Kluwer Acad. Publ.) B1/1-18
  • Boire, G. et al. (1991) Arthritis Rheum. 34, 722
  • Itoh, Y. & Reichlin, M. (1992) Autoimmunity 14, 57
  • Tsuzaka, K. et al. (1994) Arthritis Rheum. 37, 88
  • Slobbe, R.L. et al. (1992) J. Mol. Biol. 227, 361
  • Boire, G. et al. (1995) Clin. Exp. Immunol. 100, 489
  • Meheus, L. et al. (1998) 4th Dresden Symp. Autoantibodies (Abstract)
  • Deutscher, S.L. et al. (1988) Proc. Natl. Acad. Sci. USA 85, 9479
  • Ben-Chetrit, E. et al. (1989) J. Clin. Invest. 83, 1284
  • Wang, D. et al. (1996) Mol. Biol. Rep. 23, 205
  • Gaither, K.K. & Harley, J.B. (1985) Prot. Biol. Fluids Proc.Coll. 33, 413
  • Yamagata, H. et al. (1984) J. Clin. Invest. 74, 625
  • Yoshida, S. & Reichlin, M. (1990) J. Immunol. Methods 131, 113
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