icon lock Secure Shipping Worldwide
cart Shopping Cart Cart (0)
Select Currency:

ATL04

ATL04

Liver Cytosol 1

Recombinant
US $342.00
Vial Size
Qty.
Liver cytosol antigen 1
formiminotransferase cyclodeaminase
FTCD
Uniprot ID:  O95954
mRNA RefSeq:  NM_006657.2 NM_206965.1 
Protein RefSeq:  NP_006648.1 NP_996848.1
LC1 is a marker for autoimmune hepatitis (AIH) II and is found to be detected in up to 50% of cases. Immunoflourescence of LC1 is often not identified due to the brightness of LKM-1 obscuring accurate visualisation. Some occurrences of LC1 in conjunction with ANA and SMA autoantibodies, in patients with chronic hepatitis C and autoimmune hepatitis, is known. In rare case studies have shown that anti-LC1 is found as the only serological marker in 10% of patients with AIH.

The antigen recognised by LC1 antibodies has been identified as formiminotransferase cyclodeaminase (FTCD). FTCD is a bifunctional enzyme which consists of 8 identical molecular subunits of ~60kDa each arranged in a circular tetramer of dimers. FTCD catalyzes two independent but sequential reactions in the histidine degradation pathway in the mammalian liver. Each subunit consists of an N-terminal transferase active domain and a C-terminal deaminase active domain. The dimers are responsible for the separate activities of both the transferase and deaminase activity.

LC1 reactivity is mainly directed to conformation epitopes with multiple triggers along regions of  FTCD, with the majority of activity against distinct epitopes in the N-terminal FT domain. The presence of anti-LC1 antibodies seems to correlate to disease activity unlike LKM-1 in AIH II.
 
PDF-logo-dl Liver Cytosol 1 datasheet
Autoimmune Hepatitis
Please log in to view certificates of analysis for this item
0

You might also be interested in ...

Mitochondrial

Mitochondrial

ATM02
Native - Bovine Heart Muscle
US $208.00
Vial Size
Qty.
NGAL

NGAL

ATN01
Native - Human Neutrophils
US $408.00
Vial Size
Qty.
Elastase

Elastase

ATE01
Native - Human Neutrophils
US $100.00
Vial Size
Qty.
Anti-Myeloperoxidase IgG

Anti-Myeloperoxidase IgG

ABM01-10
Goat anti-Human antibody (Protein G purified)
US $218.00
Vial Size
Qty.
AROTEC Diagnostics
AROTEC have been producing and supplying premium reagents to the diagnostic industry since our incorporation in 1996
Read More
   
Contact Us

info@arodia.com

+64 4569 0361

207 Gracefield Road,
Lower Hutt, 
Wellington