icon lock Secure Shipping Worldwide
cart Shopping Cart Cart (0)
Select Currency:

ATG01-10

ATG01-10

Beta-2-Glycoprotein 1

Native - Human Plasma
US $488.00
Vial Size
Qty.
Apolipoprotein H
APOH
Activated protein C-binding protein
APC inhibitor
Uniprot ID:  P02749
mRNA RefSeq:  NM_000042
Protein RefSeq:  NP_000033
Autoantibodies directed to negatively charged phospholipids, in particular cardiolipin, have been detected in the serum of patients with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). APS is characterised by venous and arterial thrombosis, recurrent spontaneous abortions and thrombocytopenia. It is now known that a serum cofactor, β2-glycoprotein 1, is required for the binding of cardiolipin by autoantibodies in the sera of patients with APS. By contrast, anticardiolipin antibodies from patients with infectious diseases (in particular, syphilis) do not require this cofactor.

β2-Glycoprotein 1, also known as apolipoprotein H, is a relatively abundant serum protein (present at a concentration of about 0.2 mg/ml) that may play a role in coagulation. It has been shown to bind to platelets, mitochondria and negatively charged substances such as heparin, DNA, dextran sulphate and negatively charged phospholipids.

β2-Glycoprotein 1 is known to be very heat stable. On SDS-electrophoresis the protein displays an apparent molecular weight of ~55 kDa reduced and ~45kDa in non-reduced conditions. Isoelectric focussing has been reported to reveal genetic polymorphisms of β2-glycoprotein 1, the multiple bands seen by this method may be due to different amounts of sialic acid. The amino acid sequence of β2-glycoprotein 1 reveals a 326 amino acid protein of about 36 kDa. This sequence has been confirmed by sequencing the protein’s cDNA. The fact that the protein migrates on SDS-electrophoresis with a much larger apparent m.wt., suggests that it is extensively glycosylated. β2-Glycoprotein 1 has five consensus repeats, referred to as "Sushi domains", characteristic of the complement control protein family.

 
PDF-logo-dl Beta-2-Glycoprotein 1 datasheet
Antiphospholipid Syndrome
Systemic Lupus Erythematosus
Please log in to view certificates of analysis for this item
  • Hughes, G.R.V. (1994) Lancet 342, 341
  • Galli, M. et al. (1990) Lancet 335, 1544
  • Matsuura, E. et al. (1990) Lancet 336, 177
  • McNeil, H.P. et al. (1991) Proc. Natl. Acad. Sci. USA 87, 4120
  • Matsuura, E. et al. (1992) J. Immunol. 148, 3885
  • Schousboe, I. (1985) Blood 66, 1086
  • Schousboe, I. (1980) Thromb. Res. 19, 225
  • Schousboe, I. (1979) Biochim. Biophys. Acta 579, 396
  • Polz et al. (1980) Int. J. Biochem. 11, 265
  • Kroll, J. et al. (1976) Biochim. Biophys. Acta 434, 490
  • Schousboe, I. & Rasmussen, M.S. (1988) Int. J. Biochem. 20, 787
  • Wurm, H. (1984) Int. J. Biochem. 16, 511
  • Richter, A. & Cleve, H. (1988) Electrophoresis 9, 317
  • Gries, A. et al. (1989) Biochem. J. 260, 531
  • Lozier, J. et al. (1984) Proc. Natl. Acad. Sci. USA 81, 3640
  • Steinkasserer, A. et al. (1991) Biochem. J. 277, 387
  • Kato, H. & Enjyoji, K. (1991) Biochem. USA 30, 11687
  • Ichinose, A. et al. (1990) J. Biol. Chem. 265, 13411
  • Amiral, J. et al. (1994) Haemostasis 24, 191
  • Arvieux, J. et al. (1991) J. Immunol. Methods 143, 223
  • Cabral, A.R. et al. (1992) J. Autoimmunity 5, 787
  • El-Kadi, H.S. et al. (1995) J. Rheumatol. 22, 2233
  • Erickson, E.N. et al. (1996) Clin. Chem. 42, 1116
  • Gharavi, A.E. et al. (1993) J. Lab. Clin. Med. 122, 426
  • Hanly, J.G. et al. (1995) J. Rheumatol. 22, 1091
  • Hunt, J. & Krilis, S. (1994) J. Immunol. 152, 653
  • Katano, K. et al. (1996) Human Reprod. 11, 509
  • Keil, L.B. et al. (1995) Biotechnol. Appl. Biochem. 22, 305
  • Martinuzzo, M.E. et al. (1995) Brit. J. Haemotol. 89, 397
  • Matsuura, E. et al. (1992) J. Immunol. 148, 3885
  • McNally, T. et al. (1995) Brit. J. Haematol. 91, 471
  • Nomura, M. et al. (1995) Rheumatol. Int. 15, 1
  • Pengo, V. et al. (1995) Thrombosis & Haemostasis 73, 29
  • Roubey, R.A.S. et al. (1995) J. Immunol. 154, 954
  • Matsuura, E. et al. (1994) J. Exp. Med. 179, 457
  • Arvieux, J. & Roussel, B. (1994) Brit. J. Haemotol. 88, 443
  • Matsuda, J. et al. (1993) Brit. J. Haemotol. 85, 799
  • Cheng, H.W. (1996) J. Immunol. Methods 191, 87
0

You might also be interested in ...

Prothrombin

Prothrombin

ATP04-10
Native- Human Plasma
US $428.00
Vial Size
Qty.
AROTEC Diagnostics
AROTEC have been producing and supplying premium reagents to the diagnostic industry since our incorporation in 1996
Read More
   
Contact Us

info@arodia.com

+64 4569 0361

207 Gracefield Road,
Lower Hutt, 
Wellington